Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 2

Research Article

p53-Mediated PI3K/AKT/mTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines

Figure 2

PtoxDpt induced inhibition in proliferation and colony formation against hepatoma carcinoma cell lines: (a) structure of PtoxDpt; (b) growth inhibition of PtoxDpt against investigated cell lines with IC50 values μM for HCCLM3, μM for Bel-7402, and μM for HepG2 cell, respectively. (c–e) The effect of PtoxDpt on colony formation of HepG2 cells: (c) 0.75% DMSO; (d) 0.075 μM PtoxDpt; (e) 0.15 μM PtoxDpt. (f) Quantitative analyses were from five visual fields randomly chosen from each well; .

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