Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 4

Research Article

Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction

Figure 4

Ventilator decreased diaphragm perfusion. (a) Laser Doppler for diaphragm perfusion; (b) laser Doppler for soleus perfusion; (c) effects of CDIBA and MitoTEMPO on diaphragm perfusion after 12 hours of MV; (d) western blots for HIF-1α in the diaphragm and soleus. MV = mechanical ventilation; cPLA2 = cytosolic phospholipase A2; CDIBA = 4-{2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]-ethoxy} benzoic acid, a specific cPLA2 inhibitor; MitoTEMPO = a mitochondria-targeted antioxidant. and vs. the control group; vs. basal.
(a)
(b)
(c)
(d)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.