Research Article

Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction

Table 1

Arterial blood gas analysis at the end of study ().

Control ()MV ()MV+CDIBA ()MV+MitoT ()MV+CDIBA+MitoT ()

pH
PaCO2 (mmHg)
PaO2 (mmHg)
HCO3- (mM)
BE
Lactate (mM)

MV = mechanical ventilation; CDIBA = 4-{2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]-ethoxy} benzoic acid (cPLA2 inhibitor), a cPLA2 specific inhibitor; MitoT = MitoTEMPO, a mitochondria-targeted antioxidant; BE = base excess.