NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs

Figure 6

(a) High nuclear NRF1 expression (cut-off 32.5 based on ROC analysis) associated with worse melanoma-specific survival in those patients without nodal metastases at the time of diagnosis. (b) NRF1 did not separate the groups in cases with nodal metastases at the time of diagnosis. (c) High nuclear p40-NRF2 expression (highest quartile in Histoscore) predicted poor outcome within the patients with M0 disease at the time of diagnosis.

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(b)

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