NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs

Table 1

Patient cohort.

			IHC analysis	RNA analysis
Total number of patients			172	54
Age median (years)			60	67
Samples per diagnosis	Compound naevus		25	5
	Intradermal naevus		28	4
	Dysplastic naevus		46	4
	Nodular melanoma		48	15
	Superficially spreading melanoma		32	5
	Acral melanoma		9	1
	Metastasis		67	20
Number of patients with malignant melanoma			68	21
	Median age (years)		70	71
	Males		53	14
	Females		15	7
	Ulceration		19	11
	No ulceration or not defined		49	10
	Breslow	≤1 mm	11	1
		1–1.9 mm	20	0
		2–3.9 mm	13	3
		>4 mm	24	17
	Breslow mean		3.6 mm	9.2 mm
	Breslow median		2.5 mm	6.0 mm