Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Table 3

Sulforaphane dosage from lowest to highest in selected clinical trials.

Condition	~Daily SFN dose	First author	Year
Equivalent sulforaphane dose
Autism	9-14 mg (50.8–79.0 μmol)	Singh et al. [228]	2014
Nasal allergic response	18 mg (101.5 μmol)	Heber et al. [230]	2014
Asthma	18 mg (101.5 μmol)	Brown et al. [226]	2015
Chronic obstructive lung disease	19 mg (107.2 μmol)	Riedl et al. [29]	2009
Helicobacter pylori infection	30 mg (169.2 μmol)	Yanaka et al. [217]	2009
Gastric mucosal repair	30 mg (169.2 μmol)	Yanaka A. [216]	2011
Detoxification (atmospheric pollution)	36 mg (203.0 μmol)	Egner et al. [231]	2011
Type 2 diabetes	40 mg (225.6 μmol)	Bahadoran et al. [232, 233]	2012
Prostate-specific antigen (PSA) doubling time	60 mg (338.4 μmol)	Cipolla et al. [229]	2015
FRESH BROCCOLI SPROUTS
Helicobacter pylori infection	14-56 grams of fresh sprouts	Galan et al. [218]	2006
Inflammation markers in overweight	30 grams of fresh sprouts	Lopez-Chillon [209]	2018
Metabolic syndrome	100 grams of fresh sprouts	Murashima et al. [25]	2004
Glucoraphanin as myrosinase-inactive broccoli “extract”
No prevention with 6 pills branded “extract”	180 mg (0.41 mmol) GRN—not SFN	Atwell et al. [234]	2015
Sulforaphane supplement—a null response trial
Helicobacter pylori infection	2 mg (11.28 μmol)	Chang et al. [235]	2015