Review Article

Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Table 3

Sulforaphane dosage from lowest to highest in selected clinical trials.

Condition~Daily SFN doseFirst authorYear

Equivalent sulforaphane dose
Autism9-14 mg (50.8–79.0 μmol)Singh et al. [228]2014
Nasal allergic response18 mg (101.5 μmol)Heber et al. [230]2014
Asthma18 mg (101.5 μmol)Brown et al. [226]2015
Chronic obstructive lung disease19 mg (107.2 μmol)Riedl et al. [29]2009
Helicobacter pylori infection30 mg (169.2 μmol)Yanaka et al. [217]2009
Gastric mucosal repair30 mg (169.2 μmol)Yanaka A. [216]2011
Detoxification (atmospheric pollution)36 mg (203.0 μmol)Egner et al. [231]2011
Type 2 diabetes40 mg (225.6 μmol)Bahadoran et al. [232, 233]2012
Prostate-specific antigen (PSA) doubling time60 mg (338.4 μmol)Cipolla et al. [229]2015
Helicobacter pylori infection14-56 grams of fresh sproutsGalan et al. [218]2006
Inflammation markers in overweight30 grams of fresh sproutsLopez-Chillon [209]2018
Metabolic syndrome100 grams of fresh sproutsMurashima et al. [25]2004
Glucoraphanin as myrosinase-inactive broccoli “extract”
No prevention with 6 pills branded “extract”180 mg (0.41 mmol) GRN—not SFNAtwell et al. [234]2015
Sulforaphane supplement—a null response trial
Helicobacter pylori infection2 mg (11.28 μmol)Chang et al. [235]2015