The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

<div>Immunohistochemically stained liver sections for Bax expression detection. (a) Negative or very weak immunohistochemical reaction in normal control. (b) Evoked a strong positive immunohistochemical reaction marked by a dense brown colour in the cytoplasm of hepatocytes in APAP-administered rats. (c-e) Profound suppression of Bax expression in APAP-administered rats treated with the navel orange peel extract (c), naringin (d), and naringenin (e) (×200).</div>

Oxidative Medicine and Cellular Longevity

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Figure 5

Figure 5: The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats 

Figure 5 | The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats 