Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice

Figure 2

Differences in mRNA levels of UPR-related genes between the kidneys of old and young mice after high dose of tunicamycin injury: renal cortex RNA was obtained from young and old mice at baseline, 24 hours, and 72 hours after high dose of tunicamycin (0.8 μg/g) injection. The levels of GRP78, GRP94, ORP150, EDEM1, and CHOP mRNAs were measured by real-time PCR, and data was expressed as the ratio after dividing with β-actin mRNA levels at the same sample. vs. young mice at baseline. vs. young mice at 24 hours. vs. young mice at 72 hours.