RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

Table 1

List of top 25 most upregulated genes by treatment with 250 μM H₂O₂ for 48 h. These genes passed the and abs.log₂FC of 2.

Gene_ID	Gene symbol	Gene name	Log2 fold change
ENSG00000120903	CHRNA2	Cholinergic receptor nicotinic alpha 2 subunit	7.1
ENSG00000100095	SEZ6L	Seizure related 6 homolog like	6.5
ENSG00000198576	ARC	Activity regulated cytoskeleton associated protein	6.2
ENSG00000124253	PCK1	Phosphoenolpyruvate carboxykinase 1	6.2
ENSG00000137270	GCM1	Glial cells missing homolog 1	6.1
ENSG00000184647	PRSS55	Serine protease 55	5.9
ENSG00000226364	AC102948.2	No description	5.9
ENSG00000182870	GALNT9	Polypeptide N-acetylgalactosaminyltransferase 9	5.7
ENSG00000087237	CETP	Cholesteryl ester transfer protein	5.3
ENSG00000142233	NTN5	Netrin 5	5.3
ENSG00000168081	PNOC	Prepronociceptin	5.0
ENSG00000172421	EFCAB3	EF-hand calcium binding domain 3	4.8
ENSG00000172137	CALB2	Calbindin 2	4.8
ENSG00000182896	TMEM95	Transmembrane protein 95	4.7
ENSG00000178623	GPR35	G protein-coupled receptor 35	4.7
ENSG00000185739	SRL	Sarcalumenin	4.7
ENSG00000178297	TMPRSS9	Transmembrane serine protease 9	4.7
ENSG00000136099	PCDH8	Protocadherin 8	4.6
ENSG00000225899	FRG2B	FSHD region gene 2 family member B	4.6
ENSG00000167772	ANGPTL4	Angiopoietin like 4	4.5
ENSG00000168746	C20orf62	Uncharacterized protein C20orf62	4.5
ENSG00000164266	SPINK1	Serine peptidase inhibitor, Kazal type 1	4.4
ENSG00000188886	ASTL	Astacin-like metalloendopeptidase	4.3
ENSG00000156466	GDF6	Growth differentiation factor 6	4.3
ENSG00000115353	TACR1	Tachykinin receptor 1	4.3