Research Article
RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis
Table 2
List of top 25 most downregulated genes by treatment with 250
μM H
2O
2 for 48 h. These genes passed the
and abs.log
2FC of 2.
| | Gene ID | Gene symbol | Gene name | Log2 fold change |
| | ENSG00000205420 | KRT6A | Keratin 6A | -8.6 | | ENSG00000171345 | KRT19 | Keratin 19 | -8.3 | | ENSG00000163220 | S100A9 | S100 calcium-binding protein A9 | -7.9 | | ENSG00000147256 | ARHGAP36 | Rho GTPase activating protein 36 | -7.6 | | ENSG00000148346 | LCN2 | Lipocalin 2 | -7.6 | | ENSG00000086548 | CEACAM6 | Carcinoembryonic antigen related cell
Adhesion molecule 6 | -7.0 | | ENSG00000168542 | COL3A1 | Collagen type III alpha 1 chain | -7.0 | | ENSG00000057149 | SERPINB3 | Serpin family B member 3 | -6.7 | | ENSG00000087916 | SLC6A14 | Solute carrier family 6 member 14 | -6.6 | | ENSG00000124107 | SLPI | Secretory leukocyte peptidase inhibitor | -6.6 | | ENSG00000173432 | SAA1 | Serum amyloid A1 | -6.4 | | ENSG00000186081 | KRT5 | Keratin 5 | -6.4 | | ENSG00000124102 | PI3 | Protease inhibitor 3, skin-derived | -6.3 | | ENSG00000164107 | HAND2 | Heart and neural crest derivatives expressed 2 | -6.3 | | ENSG00000181541 | MAB21L2 | Mab-21 like 2 | -6.1 | | ENSG00000125810 | CD93 | CD93 molecule | -6.0 | | ENSG00000127954 | STEAP4 | STEAP4 metalloreductase | -6.0 | | ENSG00000158578 | ALAS2 | 5-Aminolevulinate synthase 2 | -5.9 | | ENSG00000162896 | PIGR | Polymeric immunoglobulin receptor | -5.9 | | ENSG00000016082 | ISL1 | ISL1 transcription factor, LIM/homeodomain | -5.9 | | ENSG00000186832 | KRT16 | Keratin 16 | -5.9 | | ENSG00000125999 | BPIFB1 | BPI fold containing family B member 1 | -5.9 | | ENSG00000129538 | RNASE1 | Ribonuclease 1 | -5.8 | | ENSG00000171401 | KRT13 | Keratin 13 | -5.8 | | ENSG00000166482 | MFAP4 | Microfibril-associated protein 4 | -5.8 |
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