RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

Table 3

Functional classes of selected differentially expressed genes with 250 μM H₂O₂ for 48 h. These genes passed the and abs.log₂FC of 2.

Putative function	Genes	Log2 fold change
Apoptosis	GADD45B	+2.6
	MACC1	-5.2
	HGF	-2.6
	GATA4	-2.0
	TP53AIP1	+1.9
	FOS	+2.6
	JUN	+2.1
	JUNB	+1.2
	FOSB	+2.6
	CARD9	+1.9
	ANXA3	-2.7
	IRF8	+3.7
	TCF4	-5.5
	HSPA1A	+2.0
	HSPA1B	+2.2
	CLU	+3.2
	TRAF1	+3.0
	TNFRSF4	+1.3
	TNFRSF12A	+1.5
	TNFRSF13C	+1.8
	GZMM	+3.5
Autophagy	GATA4	-2.0
	ATG9B	+1.7
Melanogenesis	TYRP1	-1.6
	PMEL	-1.4
	PLP1	-1.8
	HGF	-3.8
Cell cycle	PPP2R2C	+1.9
	CCND2	-3.0
	CDKN1A/p21	+0.7
WNT signaling	DKK1	+1.4
	TCF4	-5.5
	CTNNB1 (b-catenin)	-0.6
Adhesion	MACC1	-5.2
	CDH1/E cadherin	-1.8
	PTGS2	-1.4
Stress response	HSPA1A	+2.0
	HSPA1B	+2.2
Immunity	IL1B	-4.7
	IL6	+2.1
	IL17F	+3.3
	CXCL10	-5.0
	CCL2	-4.0
	CLU	+3.2
	TNFRSF4	+1.3
	TNFRSF12A	+1.5
	TNFRSF13C	+1.8
	TNFRSF25	+1.3
	IRF8	+3.7
	OASL	-1.8

- = downregulated; + = upregulated genes.