RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

Table 4

Differentially regulated transcription factors between control and 250 μM H₂O₂ for 48 h and their putative functions. These genes passed the and abs.log₂FC of 2.

Putative function	Genes	Log2 fold change
Neuronal/brain development/psychiatric/mental retardation	POU3F1	+4.0
	MYT1L	+3.8
	DLX3	+3.7
	PITX3	+3.4
	FOXJ1	+3.3
	NHLH1	+2.9
	EGR3	+2.8
	ZNF804B	+2.2
	SOX21	+2.2
	GBX1	+2.0
	BARHL2	+2.0
	TCF4	-5.5
	ZFHX4	-3.4
	MEIS2	-3.1
	SETBP1	-2.6
	TFAP2B	-2.2
Immune system	IRF8	+3.7
	FOXN1	+3.5
	TBX21	+2.7
	IKZF1	-5.3
	IRF6	-2.1
Pluripotency/EMT	MYT1L	+3.8
	SNAI1	+3.6
	SOX21	+2.2
	KLF4	+2.0
	ZEB1	-5.5
	TCF4	-5.5
	GRHL2	-2.3
Growth/proliferation/differentiation/development	FOXN1	+3.5
	SP6	+3.5
	NHLH1	+2.9
	FOXL1	+2.8
	EGR3	+2.8
	FOSB	+2.6
	EGR1	+2.5
	SOX21	+2.2
	OVOL1	+2.1
	EHF	-5.6
Insulin/diabetes	MAFA	+3.7
	INSM2	+2.2
	BARHL2	+2.0
	ISL1	-5.9
Cardiovascular	GATA5	+3.0
	HAND2	-6.2
	MEIS2	-3.1
Metabolism	FOXL1	+2.8
Skin development	OVOL1	+2.1
	KLF4	+2.0
Cell death/survival	SNAI1	+3.6
	CSRNP3	-2.8
	IRF6	-2.1

- = downregulated; + = upregulated genes.