Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism

Table 2

Quality assessment of included studies.

Study	A	B	C	D	E	F	G	H	I	J	Total
Chen et al. [20]	+	+	+			+			+		5
Dong et al. [21]	+	+	+						+	+	5
Fang et al. [22]	+		+			+					3
Huang et al.[23]	+		+								2
Jia [24]			+			+			+		3
Liu et al. [25]	+		+			+					3
Ni et al. [26]	+					+			+		3
Tian [27]		+	+			+					3
Shao et al. [28]	+		+								2
Wang [29]			+			+					2
Xu and Zhang [30]	+		+			+					3
Yao et al. [31]	+		+			+					3
Zhang et al. [32]	+	+	+			+					4
Zhang et al. [33]	+		+			+					3
Zhu et al. [34]	+		+			+					3

A: peer-reviewed publication; B: monitoring of physiological parameters such as temperature; C: random allocation; D: blinded conduct of the experiments; E: blinded assessment of outcome; F: use of anesthetic without significant intrinsic neuroprotective activity (e.g., ketamine); G: animal and/or model (aged, diabetic, or hypertensive); H: sample size calculation; I: compliance with animal welfare regulations; J: statement of potential conflict of interests.