Dehydroepiandrosterone Prevents H₂O₂-Induced BRL-3A Cell Oxidative Damage through Activation of PI3K/Akt Pathways rather than MAPK Pathways

Figure 4

Effect of DHEA on the apoptosis rate of H₂O₂-treated BRL-3A cells. (a-l) The flow cytometric histograms of different groups are represented as follows: (a) vehicle-treated group; (b) H₂O₂-treated group; (c) 1 μM DHEA and H₂O₂-treated group; (d) 10 μM DHEA and H₂O₂-treated group; (e): 100 μM DHEA and H₂O₂-treated group; (f) Trilostane and H₂O₂-treated group; (g) Trilostane, 100 μM DHEA, and H₂O₂-treated group; (h) Flutamide and H₂O₂-treated group; (i) Flutamide, 100 μM DHEA, and H₂O₂-treated group; (j) Fulvestrant and H₂O₂-treated group; (k) Fulvestrant, 100 μM DHEA, and H₂O₂-treated group; (l) testosterone, estradiol, and H₂O₂-treated group. (m) Fluorescence intensities of the different groups. Data are presented as the . . NS: no significant difference between the indicated groups.

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