The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index
Table 1
Demographic and clinical data, lipid profile, oxidized low-density lipoprotein (oxLDL), paraoxonase (PON) 1 activity, C-reactive protein (CRP), adipokines, and fractions and subfractions of lipoproteins, for the control group and end-stage renal disease (ESRD) patients under chronic dialysis.
Controls ()
ESRD patients ()
value
Demographic and clinical data
Age (years)
56.9 (52.3–59.8)
71.3 (60.0–79.6)
<0.001
Gender
14 F/8 M
87 F/107 M
0.095
Weight (kg)
65.5 (58.8–80.3)
68.7 (58.5–78.7)
0.983
Height (cm)
170 (157–175)
162 (157–170)
0.078
BMI (kg/m2)
0.073
Systolic blood pressure (mmHg)
<0.001
Diastolic blood pressure (mmHg)
<0.001
Dialysis length (years)
—
4.09 (1.74–7.60)
—
URR (%)
—
79.0 (75.8–83.0)
—
—
—
Ultrafiltration volume (ml)
—
—
Biochemical data
TC (mg/dl)
<0.001
HDLc (mg/dl)
52.6 (44.7–65.4)
46.0 (39.2–56.6)
0.022
LDLc (mg/dl)
122 (104–138)
79 (63–103)
<0.001
TG (mg/dl)
90.0 (71.3–107.5)
130.5 (97.5–178.5)
<0.001
TC/HDLc
3.70 (3.03–4.66)
3.31 (2.71–4.10)
0.119
LDLc/HDLc
2.27 (1.58–2.87)
1.73 (1.28–2.30)
0.014
oxLDL (U/l)
67.5 (55.5–73.5)
46.5 (36.5–60.0)
<0.001
oxLDL/LDLc (U/mg)
0.055 (0.049–0.064)
0.059 (0.050–0.069)
0.310
PON1 (nmol of p-nitrophenol/ml/min)
413 (386–467)
405 (361–473)
0.579
PON1/HDLc
8.43 (6.23–9.94)
9.05 (6.99–11.15)
0.107
CRP (mg/dl)
0.10 (0.04–0.21)
0.37 (0.15–0.72)
<0.001
Adiponectin (μg/ml)
5.75 (3.02–8.35)
12.28 (7.86–19.25)
<0.001
Leptin (ng/ml)
9.3 (4.9–20.6)
14.0 (5.1–41.5)
0.144
Lipoprotein fractions/subfractions
VLDL (%)
<0.001
MID-C (%)
0.054
MID-B (%)
6.6 (5.9–7.7)
7.8 (6.6–9.0)
0.004
MID-A (%)
6.3 (5.6–8.5)
6.8 (5.4–8.4)
0.941
LDL 1 (%)
18.3 (16.3–20.0)
13.0 (10.7–15.4)
<0.001
LDL 2 (%)
9.9 (7.4–13.0)
8.1 (5.6–10.9)
0.036
LDL 3-7 (%)
0.7 (0.0–1.1)
0.7 (0.0–1.7)
0.789
HDL (%)
27.0 (24.0–31.2)
26.8 (23.2–30.2)
0.793
LDL size
271 (270–272)
270 (268–272)
0.265
HDL subfractions
Large HDL (%)
24.7 (22.3–31.6)
37.2 (28.3–44.9)
<0.001
Intermediate HDL (%)
48.8 (45.9–50.6)
45.6 (41.2–49.8)
0.013
Small HDL (%)
24.9 (17.5–29.5)
17.4 (12.6–22.7)
0.001
F: female; M: male; BMI: body mass index; URR: urea reduction ratio; TC: total cholesterol; HDLc: high-density lipoprotein cholesterol; TG: triglycerides; VLDL: very-low-density lipoprotein; MID: midbands (these comprise intermediate-density lipoprotein (IDL)); LDL 3–7 corresponds to small LDL subfractions. Values are presented as median (interquartile range) or as deviation (SD).
