Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Figure 1

Two-step enzymatic reaction of glutathione synthesis. The first step is the coupling of L-glutamate and cysteine to produce γ-glutamylcysteine under the catalysis of glutamate-cysteine ligase (GCL). The second step is the coupling of γ-glutamylcysteine to glycine catalyzing by glutathione synthetase (GS). Each reaction consumes one ATP molecule. Glutathione exists in the forms of reduced GSH and oxidized GSSG.