Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Figure 4

Two degradation pathways of GSH. One way occurs outside the cell where GSH is degraded by γ-glutamyltransferase (GGT) which is expressed only on the outer surface of particular cell; the other newly discovered pathway occurs in the cytoplasm where GSH is degraded through ChaC1 and ChaC2.