SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway

Figure 7

Possible signaling transduction pathways induced by SIRT7 in LPS-treated DCMECs. SIRT7 may attenuate LPS-induced upregulation of TLR4, TAB1, and p-TAK1, deactivate the NF-κB pathway, and downregulate inflammatory cytokines (IL-1β, IL-6, and TNF-α), ROS, and NO. Subsequently, SIRT7 suppresses apoptosis-related gene expression. As a result, SIRT7 may inhibit the proinflammatory response and initiation of apoptosis in LPS-treated DCMECs.