FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

<div>Renal proximal tubular cell (RPTC) injury in patients with diabetic nephropathy (DN). (a) Representative images of hematoxylin and eosin staining, (b) periodic-acid Schiff staining, and (c) Masson’s trichrome staining in kidney biopsy specimens from patients with DN and non-DN. Scale bars, 50 <i>μ</i>m. (d) Relative basement membrane thickness in PAS staining. (e) Relative collagen fibers in Masson staining. (f) Nucleus (N), mitochondria (M) of RPTCs, and interstitial collagen fibers (F) as viewed by transmission electron microscopy. Original magnification, 4000x. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX 

Figure 1 | FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX 