Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion

Figure 2

Inhibition of RANKL-induced osteoclast differentiation by auranofin. (a, b) mRNA levels of CSTK and TRAP (). mRNA levels were determined by real-time qPCR. (c) The protein expression level of NFATc1 and CSTK (). (d) Cytotoxicity of auranofin in BMMs (). MTT assays were performed to evaluate cytotoxicity. (e) Effect of auranofin on the protein expression of NFATc1 in RANKL-treated Raw264.7 cells (). Data represents ; and compared with the control group; and compared with the RANKL-treated group.

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