Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms

Table 1

A comprehensive list of studies in this review examining the role of neurotransmitters oxidized by monoamine oxidases (MAO) in hypertensive disorders of pregnancy.

Author	Neurotransmitters	Main findings
[60, 61]	Serotonin	Increase in the urinary excretion of serotonin metabolites in preeclampsia
[59]		Elevated levels of serotonin in the placentas of preeclamptic patients compared to controls
[62]		Pregnant women exposed to serotonin had no increased risk of PE.
[73]	Adrenaline	Associated with mean arterial blood pressure in preeclamptic patients
[76]	Norepinephrine	NETs are expressed at minimal amounts in preeclamptic pregnancies.
[77]		NE concentration is increased in preeclamptic women compared to normal pregnant women.
[78]		Increase in plasma levels of norepinephrine in women with previous history of PE