Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease

Table 1

Protective effects of H₂S on hepatic fibrosis.

Experimental models	Effects	Proposed mechanisms	Refs.
Hepatic fibrosis in vivo (rat)	NaHS (56 μmol/kg/day) attenuates CCl4-induced hepatic fibrosis	Reduction of liver expression levels of AGTR1	[20]
Hepatic fibrosis in vivo (rat)	NaHS solution (10 mmol/kg body weight) shows protective effects on CCl4-induced hepatic fibrosis	Decreased expression of p38 and increased expression of phospho-Akt	[88]
Hepatic fibrosis in vivo (rat)	NaHS solution (10 mmol/kg body weight) attenuates CCl4-induced hepatic fibrosis and ECM expression	Induction of cell cycle arrest and apoptosis in activated hepatic stellate cells	[89]
Hepatic fibrosis in vivo (rat)	NaHS (56 μmol/kg/day) attenuates CCl4-induced hepatic fibrosis	Reduction of the expression of TGF-β1 and sediment of ECM in the liver tissues	[90]
Hepatic fibrosis in vitro (rat)	DATS (an H2S donor, 10 μM) reduces H2O2-induced upexpression of fibrotic protein in HSCs	Unknown	[91]

CCl₄: carbon tetrachloride; AGTR1: angiotensin II type 1 receptor; TGF-β1: transforming growth factor-β1; H₂O₂: hydrogen peroxide.