Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice

Figure 3

APOE deficiency aggravated neuronal damage in the early phase of SAH. (a) Costaining of TUNEL and NeuN showing apoptotic neurons. (d) SAH induced neuronal apoptosis in the cortex (, compared to sham, ), while the number of apoptotic neurons of APOE^-/- mice was more than that of WT mice (^##). (b) APOE deficiency aggravated β-APP accumulation in the white matter after SAH (). Low magnification (200x), high magnification (400x). (c) DTI showing FA decrease after SAH. (e) SAH induced FA decrease (, , compared to sham, ), while the FA of APOE^-/- mice in the white matter was lower than that of WT mice (^##). .

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