Nrg1 Intracellular Signaling Is Neuroprotective upon Stroke

Figure 6

Nrg1 intracellular signaling delays the onset of neurodegeneration. (a) Kaplan-Meier plot displays the surviving fractions of neurons expressing Nrg1-ICD in control and OGD conditions when compared to GFP-expressing neurons. After OGD, neurons were imaged for 8 hours. per group. Gehan-Breslow-Wilcoxon test for comparison between GFP and Nrg1-ICD upon OGD, . (b–q) Representative images of the Nrg1-ICD and GFP plotted in (a). (b–i) display normoxic controls, and (j–q) display neurons imaged after OGD at different time points. The LUT bar is shown on the left-hand side. Full arrowheads indicate neurons that survived throughout the time-lapse. Empty arrowheads depict neurons that died within 8 hours after OGD. The right bar shows the LUT. Scale bar, 50 μm.