Associations of Oxidative Stress and Postoperative Outcome in Liver Surgery with an Outlook to Future Potential Therapeutic Options

Table 2

Studies evaluating oxidative stress/ROS during liver transplantation in humans.

Reference	Year	Biomarkers	Study subjects	Results
Augusto et al. [39]	2014	rGSH, MDA, Vit. E	60 male patients between 27 and 67; Group 1 healthy volunteers; Group 2; Group 3	rGSH: MDA: ; group 1 and group 3; Vit. E: group 2 and group 3; group 3
Burke et al. [37]	2002	Urinary dinor-dihydro iPF2α-III levels	50 patients undergoing orthotopic liver transplantation	Dinor-dihydro iPF2α-III levels were elevated presurgical, rose significantly after reperfusion, became low on post-OP day 4, but never reached the levels of the healthy control group
Corradini et al. [38]	2005	7β-Hydroxycholesterol, 7-ketocholesterol	32 patients with OLT	Preoperative high 7β-hydroxycholesterol and 7-ketocholesterol levels were predictive for initial poor graft function (IPGF); postoperative increases of 7β-hydroxycholesterol and 7-ketocholesterol were nonsignificant
Tu et al. [36]	2015	Prdx6, ROS	10 DBD patients; 6 patients undergoing hemangioma surgery (=control)	Prdx6: DBD; ROS: intracellular ROS levels increase with a time of exposure to ischemia

DBD: donors after brain death; IPGF: initial poor graft function; MDA: malondialdehyde; OLT: orthotopic liver transplantation; Prdx6: peroxiredoxin 6; rGSH: reduced glutathione; ROS: reactive oxygen species.