Suppression of Alzheimer’s Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study

Figure 2

Differential expression of genes related to mitochondrial function in the hippocampus of 18-month-old OXYS rats and the effect of long-term treatment with SkQ1. (a) The Venn diagram shows overlapping sets of genes related to mitochondrial function from MitoCarta 2.0, IMPI Q3 2017, and RGD databases. (b) According to the mitochondrial gene list, the 122 DEGs in OXYS rats are related to mitochondrial function. (c) The Venn diagram suggests that treatment with SkQ1 did not affect the expression of 29 genes in OXYS rats, eliminated differences in the expression of 93 genes, and changed the expression of 13 genes. (d) The number of genes related to mitochondrial function, i.e., associated with GO terms (according to DAVID) that changed expression in control OXYS rats compared to Wistar rats.

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