Research Article
Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway
Figure 5
Activation of the SIRT3/SOD2 signaling pathway was essential to the antioxidative effects of melatonin. (a, b) The efficiency of SIRT3 siRNA was confirmed by Western blot ( per group, && vs. the scramble SiRNA group). (c–h) Western blot of SIRT3, Ac-SOD2, SOD2, cyto-c, NOQ1, and Nrf2 ( per group, and vs. the H2O2 group, # and ## vs. the H2O2 + MT group).
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