Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats
Upregulation of fibrotic biomarkers and TRPC3 in the atrium from SHR and WKY with aging. The relative mRNA and protein expressions of collagen I (left, upper panel, COL-I) (a), collagen III (right, upper panel, COL-III) (b), TGF-β1 (left, bottom panel) (c), and TRPC3 (right, bottom panel) (d). All values are presented as the of 8 rats. and significantly different compared with WKY 4m-o.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.