Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats

<div>Upregulation of fibrotic biomarkers and TRPC3 in the atrium from SHR and WKY with aging. The relative mRNA and protein expressions of collagen I (left, upper panel, COL-I) (a), collagen III (right, upper panel, COL-III) (b), TGF-<i>β</i>1 (left, bottom panel) (c), and TRPC3 (right, bottom panel) (d). 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats 

Figure 3 | Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats 