Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats
TRPC3 inhibition prevents Ang II-induced deposition of extracellular matrix protein. In cultured fibroblast, administrated Ang II (1 μmol/L) with or without Pyr3 (10 μmol/L) to measure the protein expression of TRPC3 (a), COL-1 (b), COL-III (c), and periostin (d) by Western blotting. The ratio of TRPC3, COL-I, COL-III, and periostin normalized to GAPDH was calculated. The analyzed data was shown from 5 independent experiments. All data presents the . shows a significant difference from control or from treatment with Ang II.
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