Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats
Downregulation of TRPC3 by LV-shTRPC3 suppressed the protein expression of TGF-β1. (a) GFP expression in fibroblasts under a fluorescence microscope after 72 h of infection. (b) The protein expression by Western blot analysis of TRPC3 in Blank, LV-shCtrl, and LV-shTRPC3. (c) The protein expression by Western blot analysis of TGF-β1 in Blank, LV-shCtrl, and LV-shTRPC3 (). shows a significant difference from Blank or LV-shCtrl with LV-shTRPC3.
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