Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats

<div>AT1R blocker inhibited Ang II-induced TRPC3 upregulation. The protein expressions of ATR1 (a) and AT2R (b) are measured by Western blotting from WKY and SHR with or without aging. (c) The protein expression of TRPC3 was measured by after treatment with Ang II (1 <i>μ</i>mol/L), Ang II with AT1R blocker valsartan (Val, 10 <i>μ</i>mol/L), or Ang II with AT2R blocker PD123 319 (PD, 10 <i>μ</i>mol/L) for 48hours. The analyzed data was shown from 5 independent experiments. 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or from treatment with Ang II.</div>

Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-<i>β</i>1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats 

Figure 8 | Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats 