Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1R/TGF-β1/Smad2/3 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats
AT1R blocker inhibited Ang II-induced TRPC3 upregulation. The protein expressions of ATR1 (a) and AT2R (b) are measured by Western blotting from WKY and SHR with or without aging. (c) The protein expression of TRPC3 was measured by after treatment with Ang II (1 μmol/L), Ang II with AT1R blocker valsartan (Val, 10 μmol/L), or Ang II with AT2R blocker PD123 319 (PD, 10 μmol/L) for 48hours. The analyzed data was shown from 5 independent experiments. All data presents the . shows a significant difference from control or from treatment with Ang II.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.