Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress

<div>Effect of tolfenamic acid on reactive oxygen species production in PC12 cells cultured with 3-nitropropionic acid (3-NP). PC12 cells were treated with tolfenamic acid (5 and 10 <i>μ</i>M) for 24 h and then with 3-NP (15 mM) for 8 h. DCF-DA (a) and DHE (b) were used as the fluorescent probe. 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Magnification ×10.</div>

Oxidative Medicine and Cellular Longevity

fig10

Figure 10

Figure 10: Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress 

Figure 10 | Prevention of Huntington’s Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress 