Alpha Lipoic Acid Improves Endothelial Function and Oxidative Stress in Mice Exposed to Chronic Intermittent Hypoxia

Figure 7

Summary of antioxidant and anti-inflammatory effects of ALA in mice exposed to CIH. 4-HNE: 4-hydroxynonenal; ADMA: asymmetric dimethylarginine; ALDH2: aldehyde dehydrogenase-2; ALA: alpha lipoic acid; CIH: chronic intermittent hypoxia; eNOS: endothelial nitric oxide synthase; Gpx3: glutathione peroxidase-3; Hmox1: heme oxygenase-1; IL-6: interleukin-6; MCP-1: monocyte chemoattractant protein-1; NO: nitric oxide; Nqo1: NAD(P)H dehydrogenase-1; ROS: reactive oxygen species; Sod1: superoxide dismutase-1; TNF: tumor necrosis factor alpha.