Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation

Figure 5

8-oxo-dG secretion in chronically irradiated MRC-9 fibroblast cells (a), (b) BEAS-2B or (c) HBEC-3KT cells. The cells have been exposed to a total of 0.1 (at 1.4 mGy/h) or 1 Gy (14 mGy/h). Error bars—standard deviation. Statistical analysis—Student’s -test () (a). In addition, the same cells were treated with the TGF-β in combination to radiation ((b) 0.1 or (c) 0.2 ng/ml) as described in Materials and Methods. Error bars—standard deviation. ; one-way ANOVA and Tukey’s posttest ().

(a)

(b)

(c)