Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells

Figure 4

TEM-based morphological analysis of mitochondria-ER interaction of primary cortical neurons of wt and α-syn null mice. (a) Representative images of TEM showing the mitochondria-ER interactions in primary cortical neurons of wt and α-syn null mice. ER = endoplasmic reticulum; M = mitochondria. Scale bar: 500 nm. (b) The image analysis showed an increased distance between mitochondria and ER, a decreased number of MERCs, and a decreased ratio in the number of contacts per mitochondria in α-syn null neurons when compared to wt neurons. and , unpaired two-tailed -test. Data are presented as ().

(a)

(b)