Cul4a as a New Interaction Protein of PARP1 Inhibits Oxidative Stress-Induced H9c2 Cell Apoptosis

Figure 4

Cul4a influenced H₂O₂-induced ROS formation. (a) H9c2 cells were untreated or treated with 50 μM, 100 μM, and 200 μM H₂O₂ for 2 h; ROS production increased gradually by using fluorescence microscopy. (b) Cul4a overexpression inhibited H₂O₂-induced ROS production by using fluorescence microscopy. (c) Cul4a knockdown enhanced H₂O₂-induced ROS production by using fluorescence microscopy. Scale bar = 50 μm. Cul4a: cullin 4a.

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