Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis

Figure 2

Changes in expression or activity of chromatin-modifying proteins that are redox sensitive, which lead to epigenetic reprogramming and transformation of fibroblast cells to myofibroblast cells after radiation. The red arrow indicates the increase or decrease in expression or activity driving transformation to myofibroblast. The green arrow indicates the increase in expression or activity preventing transformation to myofibroblast.