Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 4

Research Article

NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling

Figure 4

Ectopic NANOG expression and PBX1 overexpression delayed the senescence of hair follicle-derived mesenchymal stem cells (HF-MSCs) via the AKT pathway. (a, b) Western blotting showed that NANOG and PBX1 expression upregulated PARP1 and AKT signaling pathways and downregulated the expression of p16, p53, and p21 in comparison to cells in the vector control group (, ).