MicroRNA-155 Promotes Myocardial Infarction-Induced Apoptosis by Targeting RNA-Binding Protein QKI

Figure 5

Antagomir-155 protected cardiomyocytes against ischemia-induced apoptosis in a mouse MI model. (a) Representative images of TUNEL staining of cells from ventricular sections for DNA defragmentation showing the apoptotic cells (nucleus stained in blue with DAPI and apoptotic cells stained in green); . (b) Quantification analysis of total TUNEL-positive cells from different groups. (c) Serum lactate dehydrogenase (LDH) activity of different groups detected by LDH kit; . (d) C-casp3 protein expression in MI mice was detected by western blot; . vs. sham group; , vs. MI group. C-casp3: cleaved-caspase-3.

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