Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Table 4

The results of subgroup analyses.

Subgroup	No. of study and patients	Heterogeneity			SMD
		Chi^2		(%)	SMD	95% CI
Age
≤50	3/80	22.70	≤0.001	91	-0.64	-1.76 to 0.48	1.12	0.26
>50	3/190	4.93	0.09	59	0.18	-0.26 to 0.63	0.81	0.42
BMI
<35	3/203	32.64	≤0.001	94	-0.56	-1.65 to 0.53	1.00	0.32
≥35	3/67	5.54	0.06	64	0.15	-0.43 to 0.73	0.51	0.61
Daily duration
<4 h	2/39	0.09	0.76	0	-0.01	-0.45 to 0.44	0.03	0.97
≥4 h	3/211	31.97	≤0.001	94	-0.63	-1.64 to 0.38	1.22	0.22
CPAP duration
≤3 month	3/190	4.93	0.09	59	0.18	-0.26 to 0.63	0.81	0.42
>3 month	3/80	22.70	≤0.001	91	-0.64	-1.76 to 0.48	1.12	0.26
Gender
Women	2/163	0.21	0.65	0	0.00	-0.22 to 0.22	0.02	0.99
Male	5/107	37.43	≤0.001	89	-0.25	-1.12 to 0.62	0.57	0.57
Sample size
≤30	4/87	5.57	0.13	46	0.12	-0.29 to 0.53	0.58	0.56
>30	2/183	31.96	≤0.001	97	-0.87	-2.64 to 0.91	0.96	0.34
Study design
SCT	4/100	36.98	≤0.001	92	-0.29	-1.33 to 0.75	0.55	0.58
RCT	2/170	0.07	0.79	0	0.01	-0.21 to 0.22	0.05	0.96

AHI: apnea-hypopnea index, BMI: body mass index, SMD: standardized mean difference, CI: confidence interval, SCT: self-control trials, RCT: randomized controlled trials.