AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction

<div>AT1R blocker losartan inhibits Ang II-induced apoptosis of BMMSCs. (a) Poly Caspase and DAPI staining showing the apoptosis of BMMSCs after pretreatment with 10 <i>μ</i>M losartan followed by exposure to 10 <i>μ</i>M Ang II. (b) Quantification of the numbers of caspase-positive cells. (c) Quantification of the numbers of the cells with condensed and/or fragmented nuclei. (d and e) Western-blotting assay showing Bcl2 and Bax expression in BMMSCs after pretreatment with losartan followed by exposure to 10 <i>μ</i>M Ang II. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: AT1R-Mediated Apoptosis of Bone Marrow Mesenchymal Stem Cells Is Associated with mtROS Production and mtDNA Reduction 