Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity

Figure 4

Method for the modulation of nucleotide excision repair. Nucleotide excision repair is modulated by various signaling pathways that enhance its activity including CSNK2A1, Nrf2, and MAPK. This enhancement can also be mediated by several chemical molecules. On the other hand, the inhibition of NER can be mediated by either miRNAs that target NER genes or by chemical drugs normally used in combination with chemotherapies.