tert-Butylhydroquinone Treatment Alleviates Contrast-Induced Nephropathy in Rats by Activating the Nrf2/Sirt3/SOD2 Signaling Pathway
Effects of t-BHQ on CIN-induced oxidative stress in the kidney of CIN rats. (a) ROS level. (b) Malondialdehyde (MDA) level. (c) SOD2 activity. (d) GSH/GSSG ratio. Rats in the ioversol group were sequentially injected in the tail vein: indomethacin (10 mg/kg), followed by L-NAME (100 mg/kg) and ioversol (2.9 g/kg) 15 and 30 min later. t-BHQ was administered to rats in the t-BHQ+ioversol group. Data were expressed as the . versus the control group; & versus the ioversol group.