| Active principle/preparation | Main constituents | Tests | Model | Dosage | Results | Reference |
| Raw material | Oviductus ranae | Acute toxicity | Mice (in vivo) | 2.5-20 g/kg BW, i.g., single-dose administration, followed by an observation of 14 days | BW | [19] | Subacute toxicity | Rats (in vivo) | 1.75, 3.5, and 7 g/kg BW, i.g., for 28 days | BW | Ames test | Salmonella typhimurium strains (in vitro) | 8-5000 μg/plate | None | Micronucleus test | Mice (in vivo) | 2.5, 5, and 10 g/kg BW, i.g., for 2 days | None | Sperm malformation assay | Mice (in vivo) | 2.5, 5, and 10 g/kg BW, i.g., for 5 days, followed by an observation of 30 days | None | Active principle | Protein-rich extract from Oviductus ranae | Acute toxicity | Mice (in vivo) | 5, 10, and 20 g/kg BW, i.g., single-dose administration, followed by an observation of 14 days | BW | [84] | Compound Danggui-Shuangshen-Hamayou tablet | Ginseng, Angelica sinensis, Salviae miltiorrhizae, and Oviductus ranae | Acute toxicity | Mice (in vivo) | 20 g/kg BW, i.g., single-dose administration, followed by an observation of 7 days | BW | [148] | Micronucleus test | Mice (in vivo) | 2.5, 5, and 10 g/kg BW, i.g., for 2 days | None | Sperm malformation assay | Mice (in vivo) | 2.5, 5, and 10 g/kg BW, i.g., for 5 days, followed by an observation of 30 days | None | Hamayou soft capsule | Oviductus ranae | Ames test | Salmonella typhimurium strains (in vitro) | 0.313-5 g/plate | None | [149] | Micronucleus test | Mice (in vivo) | 0.94-7.5 g/kg BW, i.g., for 4 days | None | Sperm malformation assay | Mice (in vivo) | 1.88, 3.75, and 7.5 g/kg BW, i.g., for 5 days, followed by an observation of 30 days | None |
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