Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer

Figure 2

The alcohol-induced modulation of Brf1 expression. Alcohol increases Brf1 expression through two ways in breast cells. One is that alcohol activates JNK1 and MSK1 to upregulate Brf1 expression; another way is that alcohol activates JNK1 to enhance ERα and Runx2 expression, leading to augmenting Brf1 expression. The two pathways increase RNA Pol III gene, eventually resulting in cell proliferation and transformation and mammary tumor development, while Tam inhibits ERα activity and decreases the cellular level of Brf1.