Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer

Figure 3

Alcohol-induced histone H3 phosphorylation which upregulates Brf1 expression. Alcohol induces activation of MSK1, which binds to the sites of chromatin of the target genes. Activated MSK1 mediates histone H3 phosphorylation (H3ph) to cause chromatin remodeling at local, leading to increases in Brf1 transcription. P: the phosphorylation group.