Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1α in H9c2 Cells
Protective effects of propofol against high glucose stress in H9c2 cells. Propofol (5, 10, 20, and 40 μM) adopted during the entire high glucose culture phase. The control group was defined as 100%. (a) Effect of different concentrations of glucose on cell viability in H9c2 cells. Cell viability was assessed by measuring the MTT reduction. (b) Effects of different concentrations of propofol on cell viability under high glucose conditions in H9c2 cells. (c) Effects of propofol on high glucose-induced intracellular ROS levels in H9c2 cells. (d) Effects of different concentrations of propofol on the secretion of proinflammatory cytokines induced by high glucose in H9c2 cells. The results were shown as from five independent experiments. ,, and versus control; #,##, and ### versus the high glucose-treated group without drugs. Ctrl = blank control group; 0 = high glucose model group; P5 = 5 μM propofol pretreatment group; P10 = 10 μM propofol pretreatment group; P20 = 20 μM propofol pretreatment group; P40 = 40 μM propofol pretreatment group; and HG = 22 mM high glucose culture.
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