CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway
CD28 deficiency inhibits the blast exposure-induced expression of ROS and oxidative stress. (a) Representative ROS images from the lung tissues (). (b–e) Representative western blot images and quantitative analysis of MDA5, IREα, SOD-1, and β-actin. Fold changes of WT (green bar) and CD28-/- (red bar) expressions are shown. All experiments were repeated at least three times. Results are expressed as the ( per group). versus the control group; versus the WT group (two-way ANOVA; Bonferroni post hoc test). WT: C57BL/6 wild-type mice; CD28-/-: CD28 knockout mice.
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