FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics

<div>FGF21 regulates mitochondrial dynamics via mediation of AMPK activation. (a) Western blotting and quantitative analysis of the level of p-AMPK in BM-MSCs at P4 and P12 (i, ii). (b) Western blotting and quantitative analysis of the level of p-AMPK, p-Drp1, and Mfn2 in BM-MSCs at P4 from the control siRNA or FGF21 siRNA or FGF21 siRNA+AICAR-treated group (i, ii). (c) Representative images of SA-<i>β</i>-gal staining in BM-MSCs at P4 from the control siRNA or FGF21 siRNA or FGF21 siRNA+AICAR-treated group (i). Percentage of SA-<i>β</i>-gal-positive senescent cells in control siRNA or FGF21 siRNA or FGF21 siRNA+AICAR-treated BM-MSCs at P4 (ii). 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics 