Pasteurized Orange Juice Rich in Carotenoids Protects Caenorhabditis elegans against Oxidative Stress and β-Amyloid Toxicity through Direct and Indirect Mechanisms

Figure 6

Effect of pasteurized juice from oranges cv. ‘Bahia’ and cv. ‘Cara Cara’ treatment on the β-amyloid induced paralysis in C. elegans transgenic model of Alzheimer’s disease. Paralysis curves for C. elegans strain CL2006 which expresses β-amyloid peptide constitutively in the muscle. Worms were treated beginning at L4 with 2% POJ for 48 h at L4 stage. Paralysis was verified at 1 h intervals at 35°C. compared to untreated control and comparing 2% ‘Bahia’ with 2% ‘Cara Cara’ juice by log-rank (Mantel-Cox) test.